Gene Expression
Multiplex PCR Panels
| Inflammation Assays |
- Panel (# of Genes)
- Immunotoxicity Plex (25)
- Inflammatory Plex (27)
- Sepsis Plex, 2 gene sets (44) |
| Cancer Assays |
- Breast Cancer Plex (29)
- Metastasis Plex (20)
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| Tox and Specialty |
- Chemo Response Plex (19)
- Growth Reg II Plex (24)
- Metabolism Plex (22)
- Multitox Plex (26)
- Multistress Plex (23)
- Nephrotoxicity Plex (24)
- Reference Plex (26)
- Transport Plex (27)
- Stem Cell Plex (24)
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Custom Services
- Custom Multiplex PCR Panels
- Compound Testing/Screening (in vivo, in vitro)
- siRNA Validation
- Microarray Data Validation
Full incorporation of Quality Programs
- GLP
- Non-GLP
- CLIA (Q1, 2009)
Sample Access
- Prospective Trials
- Prospectively designed retrospective trials
- Fixed sample collections
- Formalin-fixed paraffin-embedded tissues
- Fine needle aspirates
- Cell Culture
- Animal models
Sample Prep and Process
- Automated and manual methods
- Blood/urine/tissue/cells
- Microdissection from tissue sections
- Robust quality control (QC) procedures
- Sample processing using a barcode system
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Genotyping
- Single mutation detection
- SNP analysis
- Targeted PCR sequencing
- Gene Mutation Panels:
- EGFR (29 mutations)
- k-Ras (7 mutations)
- b-Raf (1 main mutation)
- Custom Panels (up to 44 mutations)
- Cyp450 isoform variants (in development)
- Drug resistance (in development)
Analysis Platforms
- Gene Detection/Quantification
- XP-PCR Multiplex quantitative PCR
- XP-PCR Short Fragment (FFPE)
- TaqMan
- Affymetrix GeneChip (for regular samples, small amount samples and FFPE samples)
- Standard panels
- Custom assay development
- Tech transfer of developed assays to client labs
Data Analysis
Microarray Data Analysis
- Standard and customized data summarization and normalization
- Differential gene expression
- Clustering and principal component analysis
- Pathway and Gene Ontology enrichment analysis
- Statistical graphics
XP-PCR Multiplex Data Analysis
- Optimized data normalization (multiple control genes)
- Customized outlier detection and reduction
- Differential gene expression
- Clustering and principal component analysis
- Pathway and Gene Ontology enrichment analysis
- Statistical graphics
Data Analysis Consulting
- Experimental design and planning
- Predictive signature modeling
- Survival analysis
- Advanced statistical graphics
- Customized third-party data analysis
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