Therapies do not always correlate well with pharmacological response in treatment. Drugs act at a molecular level that is not necessarily reflected by the overall phenotype of the targeted tissue.
Genetic analysis can provide deeper insight on:
- the molecular activities within a diseased tissue
- the likelihood to respond to therapy by looking at specific characteristics associated with the drug target
- the up and downstream pathways
By focusing down to the molecular level one can directly measure characteristics that predict drug response.
