PKDM

Uncover further PKDM properties of your compounds in early development

We have developed a single assay for monitoring the expression of the most critical genes in the cytochrome, phase II enzyme, and transporter families. Using this tool, our clients can quickly determine the baseline of these critical elements in PKDM, or monitor the impact a compound has on their expression and thus on its pharmacokinetics, distribution and excretion.

Cytochromes, Phase II enzymes & transporters all play a role in PKDM rates of drug candidates

All ingested drugs are metabolized by some type of cytochrome, and the biproducts of these reactions are glucuronidated by UDP-Glucuronosyltransferasee, which are phase II biotransformation enzymes. Glucuronidation increases the solubility of these compounds and allows for the renal and biliary excretion of these byproducts. Transporters on the surfaces of cells in the intestine, liver and other tissues facilitate the absorption, distribution, and excretion of drugs.

To learn more about uncovering further PKDM properties of your compounds in early development, please
contact us.